A different sequencing method that chemically cleaved DNA at specific bases, developed by Allan Maxam and Walter Gilbert, was the dominant technology into the 1980s. Radiolabeled DNA samples were incubated in four separate reactions, each of which contained a chemical that cleaved after a different nucleotide — either A/G, G, C, or C/T. By adding the right amount of each chemical, it was possible to produce different fragments chopped off at each individual base. The sequence could then be read using gel electrophoresis and autoradiography. Maxam–Gilbert sequencing was easier than the plus and minus method to run and interpret, but was eventually surpassed by Sanger’s chain termination method, which molecular biologists found both technically preferable and more “elegant” since it mirrored the natural copying of DNA.
Whether the Moon appears red in color or not, with just your naked eye tonight you can see the Aristarchus Plateau and Mares Imbrium and Serenitatis. If you have binoculars, you should also catch a glimpse of the Mare Nectaris, Alps Mountains and Clavius Crater. If you have a telescope, pull it out for the Blood Moon and to try and see the Linne Crater, Rupes Altai, and the Rima Hyginus.
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