Cython's ** operator with float exponents. Even with typed doubles and -ffast-math, x ** 0.5 is 40x slower than sqrt(x) in Cython -- the operator goes through a slow dispatch path instead of compiling to C's sqrt(). The n-body baseline uses ** (-1.5), which can't be replaced with a single sqrt() call -- it required decomposing the formula into sqrt() + arithmetic. 7x penalty on the overall benchmark.
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This does not solve the DMA problem directly (a DMA attack device physically attached to the PCIe slot bypasses all of this), but it closes some of the software-assisted DMA attack paths.